Synthetic Studies on Polymaxenolides: Synthesis and Structure Elucidation of Nominal Epoxyafricanane and Other Africane-Type Sesquiterpenoids

A racemic total synthesis of the sesquiterpenoid unit of the hybrid marine natural product polymaxenolide has been achieved based on a three-component assembly followed by ring-closing metathesis as the key steps. However, the spectral data of our product synthesized from Δ9(15)-africanene by epoxidation were not identical with those of the natural product named epoxyafricanane. The structure confirmation of the synthetic nominal epoxyafricanane is described.本研究以三组分组装及闭环复分解（ring-closing metathesis）为关键步骤，成功完成了杂合海洋天然产物polymaxenolide倍半萜单元的外消旋全合成。然而，本研究通过Δ9(15)-非洲烯经环氧化反应制备的合成产物，其光谱数据与天然产物epoxyafricanane的光谱数据并不一致。本文对合成得到的标称环氧非洲烷（epoxyafricanane）的结构确证工作进行了阐述。