Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-425

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-425 Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-{4-methoxy-3-[(2-methoxyphenyl)methoxy]phenyl}-2-(1-{thieno[3,2-d]pyrimidin-4-yl}piperidin-4-yl)-1,2,4a,5,8,8a-hexahydrophthalazin-1-one, ... Authors: Singh, A.K, Brown, D.G. Deposit date: 2018-02-20 Release date: 2019-03-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: hPDE4D2 structure with inhibitor NPD-425 To be published

人类磷酸二酯酶4D2（phosphodiesterase 4D2）催化结构域与抑制剂NPD-425的晶体结构。描述项：1,2-乙二醇（1,2-ETHANEDIOL）、4-(2-羟乙基)-1-哌嗪乙磺酸（4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID）、4-{4-甲氧基-3-[(2-甲氧基苯基)甲氧基]苯基}-2-(1-{噻吩并[3,2-d]嘧啶-4-基}哌啶-4-基)-1,2,4a,5,8,8a-六氢酞嗪-1-酮等。作者：Singh, A.K.、Brown, D.G.。提交日期：2018-02-20；发布日期：2019-03-20；最后修改日期：2024-01-17。实验方法：X射线衍射（X-RAY DIFFRACTION，2.1埃（Å））。引用信息：含抑制剂NPD-425的人PDE4D2结构，待发表。