Dataset supporting the publication "Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity"

Dataset supporting the publication "Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity", J. Biol. Chem, 2014, 289, 9340-9351. DOI: 10.1074/jbc.M113.533315 Authors: Faure, L.; Nagarajan, S.; Hwang, H.; Montgomery, C. L.; Khan, B. R.; John, G.; Koulen, P.; Blancaflor, E. B.; Chapman, K. D. The dataset includes the original raw data of the N-Acylethanolamines (NAEs) synthesized (NMR data, Mass spectral data of compounds 5 and 6. i.e. 5, PDP-EA (N-(2-hydroxyethyl)-2-(3-n-pentadecylphenoxy)acetamide); and 6, cardanol-EA (mixture of phenoxyacyl-ethanolamides). Which includes the raw data and graphical plots. Shart Abstract: N-Acylethanolamines (NAEs) are involved in numerous biological activities in plant and animal systems. The metabolism of these lipids by fatty acid amide hydrolase (FAAH) is a key regulatory point in NAE signaling activity. Several active site-directed inhibitors of FAAH have been identified, but few compounds have been described that enhance FAAH activity. Here we synthesized two sets of phenoxyacyl-ethanolamides from natural products, 3-n-pentadecylphenolethanolamide (5) and cardanolethanolamide (6), with structural similarity to NAEs and characterized their effects on the hydrolytic activity of FAAH.

本数据集为发表于《生物化学杂志》（*Journal of Biological Chemistry*）2014年第289卷第9340-9351页的论文《苯氧基酰基乙醇酰胺的合成及其对脂肪酸酰胺水解酶活性的影响》提供数据支撑，DOI: 10.1074/jbc.M113.533315。作者：Faure, L.; Nagarajan, S.; Hwang, H.; Montgomery, C. L.; Khan, B. R.; John, G.; Koulen, P.; Blancaflor, E. B.; Chapman, K. D.

本数据集包含所合成的N-酰基乙醇胺（N-Acylethanolamines, NAEs）的原始数据，具体包括化合物5与6的核磁共振波谱（NMR）数据及质谱数据：其中化合物5为PDP-EA（N-(2-羟乙基)-2-(3-正十五烷基苯氧基)乙酰胺）；化合物6为腰果酚乙醇酰胺（cardanol-EA，即苯氧基酰基乙醇酰胺混合物），同时包含原始数据与相关图表。

研究摘要：N-酰基乙醇胺（NAEs）广泛参与动植物体内的多种生物学活动。脂肪酸酰胺水解酶（fatty acid amide hydrolase, FAAH）介导的这类脂质代谢是NAE信号通路活性的关键调控节点。目前已鉴定出多种靶向FAAH活性位点的抑制剂，但鲜有能够增强FAAH活性的化合物被报道。本研究从天然产物中合成了两类苯氧基酰基乙醇酰胺类化合物——3-正十五烷基苯酚乙醇酰胺（化合物5）与腰果酚乙醇酰胺（化合物6），二者结构与NAEs具有相似性，本研究对其调控FAAH水解活性的效果进行了表征。