hydrogen regulate placental inflammation to reduce the BPD

Hydrogen (H2) has recently received considerable attention as a therapeutic agent owing to its novel anti-inflammatory property. Excessive activation of the placental inflammation is recognized as a major cause that leads to bronchopulmonary dysplasia (BPD). This study aimed to investigate the protective effect of H2 on lipopolysaccharide (LPS)-induced BPD and to explore its potential anti-inflammatory signaling mechanisms in the placenta. RNA sequencing was used to examine differentially expressed mRNA levels and Bioinformatics analysis (GO and KEGG) of RNA-seq were applied to clarify the mechanisms of the anti-inflammatory effect of H2 on LPS-induced BPD.