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Genome-wide maps of chromatin modifications in a breast cancer cell line

NIAID Data Ecosystem2026-03-12 收录

癌症表观遗传调控

CDK19/CDK8功能研究

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103887 数据链接链接失效反馈

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资源简介：

We report the H3K27ac status in MDA-MB231 breast cancer cells after knockdown of CDK19 and CDK8. Examination of histone marks using a breast cancer cell line transduced with control shRNA or shRNA to knockdown CDK19 and CDK8

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创建时间：

2021-07-25

三阴性乳腺癌基因表达

CDK19/CDK8功能研究

When CDK19 was initially discovered, it was assumed that CDK19 played a redundant role to CDK8 because they share 84% amino acid sequence similarity. However, biological clues such as CDK19s different

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Loss of KDM6A enhances human pancreatic cancer progression and potentiates HDAC inhibitor lethality via restoring CDKN1A

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HDAC抑制剂药物敏感性

BACKGROUND & AIMS: Although genomic analysis have recently discovered the malignant subtype of human pancreatic ductal adenocarcinoma (PDAC) characterized by frequent mutations of a histone modifier K

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Study of MED1 acetylation in ER positive breast cancer cells [CUT&Run]

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MED1乙酰化转录调控

Chromatin occupancy of MED1 and other Mediator components, as well as Pol II, were studied in MCF7 cells. MED1 acetylation affects chromatin occupancy of its related factors, which was analyzed with C

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ARID1A is a critical regulator of luminal identity and therapeutic response in oestrogen receptor-positive breast cancer (ChIP-seq II). ARID1A is a critical regulator of luminal identity and therapeutic response in oestrogen receptor-positive breast cancer (ChIP-seq II)

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内分泌治疗耐药机制

Mutations in ARID1A, a subunit of the SWI/SNF chromatin remodelling complex, are the most common somatic alteration of the SWI/SNF complex across all cancers including oestrogen receptor positive (ER)

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Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway (ChIP-seq)

癌症表观遗传调控

ChIP-seq分析

Brg1 is a subunit of SWI/SNF chromatin remodeling complex. To clarify the role of Brg1 for the progression and metastasis of pancreatic ductal adenocarcinoma (PDAC), we generated a PDAC mouse model wi

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Genome-wide maps of chromatin modifications in a breast cancer cell line

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