Cancer-Associated Fibroblast-derived exosomal LINC02420 drives glycolytic reprogramming via AEG-1/HIF-1α to promote Laryngeal Cancer progression

Laryngeal squamous cell carcinoma (LSCC) has an insidious onset and strong heterogeneity. The lack of effective biomarkers makes early diagnosis difficult. Liquid biopsy technology provides a new direction to break through this bottleneck. The co-culture model of CAFs and LSCC cells confirmed that CAFs can promote LSCC glycolysis through exosomes to promote its malignant progression. Further screening of differential lncRNAs that drive LSCC glucose metabolism reprogramming and promote tumor progression was performed using exosome lncRNA chips. The Agilent platform was used to analyze the differentially expressed lncRNAs in CAFs-derived exosomes and NFs-derived exosomes from six pairs of LSCC patients using human lncRNA array.