Genome-wide significant and replicated loci for serum calcium in Europeans.

P values are corrected for inflation using genomic control. Replication criteria: overall genome-wide significance (PP2 was zero for rs1801725, rs1550532, rs10491003, rs7336933 and rs1570669 (I2P>0.20). For rs780094 and rs7481584, I2 were 0.79 and 0.43 with I2P 0.03 and 0.19, respectively. For these latter SNPs, sample size weighted meta-analysis P values were 2.93E-10 and 2.03E-10, respectively.Chr, chromosome. Effect A1 = beta regression coefficient for allele A1; SE, standard error.*one-sided P values.P值采用基因组控制（genomic control）法进行通胀校正。 复制标准如下：需达到全基因组显著性水平。对于rs1801725、rs1550532、rs10491003、rs7336933及rs1570669这几个位点，PP2值为0（I²P>0.20）。对于rs780094与rs7481584两个位点，其I²值分别为0.79与0.43，对应的I²P值分别为0.03与0.19。针对这后两个单核苷酸多态性（SNP，single nucleotide polymorphism）位点，经样本量加权的荟萃分析（meta-analysis）P值分别为2.93×10^-10与2.03×10^-10。 Chr：染色体（chromosome）。效应值A1为等位基因A1的β回归系数；SE为标准误（standard error）。*单侧P值。