[3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2‑Alkenylindoles: An Approach to Tetrahydro-β-carbolinones

A novel [3 + 3] cycloaddition between in situ formed azaoxyallyl cations and 2-alkenylindoles has been developed. This concise method allows the efficient construction of a series of tetrahydro-β-carbolinones in good yields under mild conditions. Gram-scale experiments and further derivatization of tetrahydro-β-carbolinones highlighted the potential utility of our method.本研究开发了一种基于原位生成的氮氧烯丙基正离子（azaoxyallyl cations）与2-烯基吲哚（2-alkenylindoles）的新型[3+3]环加成反应。该方法简洁高效，可在温和反应条件下以良好收率构建一系列四氢-β-咔啉酮（tetrahydro-β-carbolinones）类化合物。克级规模实验以及对四氢-β-咔啉酮类化合物的进一步衍生化，充分彰显了本方法的应用潜力。