Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines
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https://figshare.com/articles/dataset/Titanium_IV_Catalyzed_Stereoselective_Synthesis_of_Spirooxindole_1_pyrrolines/2045952
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资源简介：
A stereoselective
cyclization between alkylidene oxindoles and
5-methoxyoxazoles has been developed using catalytic titanium(IV)
chloride (as low as 5 mol %) to afford spiro[3,3′-oxindole-1-pyrrolines]
in excellent yield (up to 99%) and diastereoselectivity (up to 99:1).
Using a chiral scandium(III)–indapybox/BArF complex affords
enantioenriched spirooxindole-1-pyrrolines where a ligand-induced
reversal of diastereoselectivity is observed. This methodology is
further demonstrated for the synthesis of pyrrolines from malonate
alkylidene and coumarin derivatives.
创建时间：
2015-12-17
