p63/p73 maintain cancer stem cells in a quasi-mesenchymal state and drive metastatic colonization via EGFR signaling [ChIP-Seq]

p63/p73 are master transcriptional regulators of ITGB4-hi cancer stem cells and are required to maintain CSCs in a quasi-mesenchymal state and for metastatic colonization Overall design: ChIP-seq of SUM159 ITGB4-hi or SUM159 ITGB4-low cells. ChIP-seq of rescue experiment in ITGB4-hi cells with knockout of p63/p73 (double KO, dKO). dKO cells were engineered to ectopically express a control empty vector (EV), dNp63, TAp73, or both dNp63/TAp73 (dual). ITGB4-lo cells were engineered to express a control empty vector (EV) or dNp63.