Pangenome, Transcriptome and Transposon Mutagenesis Studies in Pathogenesis and Virulence Factors of Shigella Sonnei Associated With Caenorhabditis Elegans Infection

This thesis investigates the important Shigella sonnei virulence factors during the nematode host infection. It identifies several genes involved in biofilm formation and acid resistance as important genes for Shigella sonnei to maintain its infection in the host. These genes are potential targets for new antibiotic drug development in the future.