Human pluripotent stem cells (hPSCs) are an important player in disease modeling and regenerative medicine. Nonetheless, multiple studies uncovered their inherent genetic instability upon prolonged cu
We used eXcision Repair-sequencing (XR-seq) to map UV induced damage in U2OS cells and in U2OS cells in which CSA or UVSSA genes were knocked out. Complementation of UVSSA knockout with WT or mutant p
Here we report single nucleus RNA-seq shows in 5xFAD mouse model of AD and WT, showing changes in the composition and state of multiple cell types. In particular, we identified a unique population of
