Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals

Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals Descriptor: 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE, ... Authors: Andersen, O.A, Schonfeld, D.L, Toogood-Johnson, I, Felicetti, B, Albrecht, C, Fryatt, T, Whittaker, M, Hallett, D, Barker, J. Deposit date: 2009-04-02 Release date: 2009-07-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Cross-Linking of Protein Crystals as an Aid in the Generation of Binary Protein-Ligand Crystal Complexes, Exemplified by the Human Pde10A-Papaverine Structure. Acta Crystallogr.,Sect.D, 65, 2009

通过配体浸泡交联蛋白质晶体获得的人类磷酸二酯酶（PDE）-罂粟碱复合物。描述项：1-(3,4-二甲氧基苄基)-6,7-二甲氧基异喹啉、环腺苷单磷酸（cAMP）及受cAMP抑制的环鸟苷单磷酸3',5'-环磷酸二酯酶，…… 作者：Andersen, O.A.、Schönfeld, D.L.、Toogood-Johnson, I.、Felicetti, B.、Albrecht, C.、Fryatt, T.、Whittaker, M.、Hallett, D.、Barker, J. 存档日期：2009-04-02；发布日期：2009-07-28；最后修改日期：2024-01-31 实验方法：X射线衍射（2.8埃） 引用文献：《蛋白质晶体交联法助力二元蛋白质-配体晶体复合物的构建——以人类PDE10A-罂粟碱晶体结构为例》，发表于《晶体学报D辑》，2009年，第65卷。