Reduced representation bisulfite sequencing in liver of rats exposed to glyphosate, MON 52276, and a mixture of pesticides

Human health effects from chronic exposure to pesticide residues are little investigated. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in an in vivo subchronic toxicity test of a glyphosate, its formulated product MON 52276, and mixture of six pesticide active ingredients frequently detected in foodstuffs (azoxystrobin, boscalid, chlorpyrifos, glyphosate, imidacloprid and thiabendazole). Sprague-Dawley rats were administered with the pesticide mixture with each ingredient at its regulatory permitted acceptable daily intake. Evaluation of methylation profiles in liver of rats exposed to glyphosate, MON 52276, and a mixture of pesticides