Supplementary Material for: Introduction of Hypothermia for Neonates with Perinatal Asphyxia in the Netherlands and Flanders

Background: Therapeutic hypothermia was introduced in the Netherlands and Flanders, Belgium, in 2008. Since then, an increasing number of patients has been treated - up to 166 in 2010. Complications and outcome were registered in an online database. Objectives: The aim of this study was to analyse complications and outcome after implementation. Methods: Data were retrieved from an online database to which all centres had contributed. Results: In 3 years, 332 patients were treated. Excluding 24 patients with congenital abnormalities or metabolic disorders, mortality was 31.8%. Of the 210 survivors without congenital malformations, 21 had cerebral palsy, another 19 a developmental delay of more than 3 months at the age of at least 24 months, and 2 had severe hearing loss. The total adverse outcome, combining death and adverse neurodevelopment, in 308 patients without congenital malformations is 45.5%, which is similar to that of the large trials. Conclusions: The introduction of therapeutic hypothermia for neonates with perinatal asphyxia in the Netherlands and Flanders has been rapid and successful, with results similar to findings in the randomised controlled trials.背景：治疗性低温（therapeutic hypothermia）于2008年在荷兰及比利时佛兰德斯地区引入。自此之后，接受该疗法治疗的患者数量逐年攀升，2010年达到166例。患者的并发症与预后情况均通过在线数据库进行登记备案。 研究目标：本研究旨在分析该疗法推广应用后的并发症发生情况与患者预后结局。 研究方法：研究数据从所有参与中心共同维护的在线数据库中提取获取。 研究结果：3年内共收治332例患者。排除24例存在先天性畸形或代谢紊乱的患者后，总病死率为31.8%。在210例无先天性畸形的存活患者中，21例罹患脑瘫（cerebral palsy），19例在至少24月龄时出现超过3个月的发育迟缓，另有2例存在重度听力损失。针对308例无先天性畸形的患者，合并死亡与不良神经发育结局的总不良预后率为45.5%，该结果与大型临床试验的报道数据相近。 研究结论：荷兰及比利时佛兰德斯地区针对围产期窒息（perinatal asphyxia）新生儿开展治疗性低温疗法的推广工作进展迅速且成效显著，所得结果与随机对照试验的研究结论高度一致。