Defining the responses governing disease tolerance during Citrobacter rodentium infection of mice by deep RNA sequencing. Mus musculus

We performed deep RNA sequencing and systematically analyzed the global gene expression profiles of C. rodentium-infected colon tissues from both susceptible and resistant congenic mice strains to determine the common transcriptomic responses to infection and the Rspo2-mediated dysregulated pathway signatures associated with the loss of disease tolerance. Overall design: C. rodentium infection in OuJ and O.B6 mice strains