Transcriptional profiline of murine and human T cell populations

T-regulatory-type-1 (TR1) cells comprise a phenotypically heterogenous but prevalent subset of Tregs that arise from unknown precursors in response to ill-defined cues. Here, we perform detailed transcriptional studies of autoantigen-specific TR1-like cell pools arising in response to peptide-major histocompatibility complex class II-coated nanoparticles (pMHCII-NPs) and compare them to other T cell populations to define their unique features. Transcriptional characterization of autoantigen-specific TR1-like cell pools and other T cell populations in mice and human.