Ir-Catalyzed Regio- and Enantioselective C–H Addition to 1,1-Disubstituted Alkenes Enabled by the Directing Group: Construction of Acyclic Quaternary Stereocenters

All-carbon quaternary stereocenters are prevalent in
many natural
products and pharmaceuticals, yet their efficient and selective construction
still remains challenging. Here we report iridium-catalyzed regio-
and enantioselective hydroheteroarylation of 1,1-disubstituted alkenes.
Taking advantage of an appropriate directing group, the all-carbon
quaternary stereocenters were constructed with high enantioselectivities.
The directing group was easily removed under mild reaction conditions,
and thus, the synthetic utility of the product was also demonstrated.