Supporting data for "INTERACTION OF ADIOCYTES AND CANCER CELLS TO PROMOTE BREAST CANCER GROWTH IN CCL/CCR7 CHEMOKINE AXIS"

Cancer-associated adipocytes (CAAs) are one of the compositions in breast cancer tumor microenvironment (TME), which were smaller, fewer lipids, fewer differential markers, and had cancer-promoting effects. CAAs secrete several cytokines to influence cancer cells including hormones, interleukins, and chemokines. Studies revealed that CAAs can secrete CCL5 and CCL2 to promote breast cancer cells. However, study on the expression level and functions of CCL19 and CCR7 in breast cancer is limited. Thus, we aim to evaluate the interaction between adipocytes and breast cancer cells through the CCL/CCR7 chemokine axis.癌相关脂肪细胞（Cancer-associated adipocytes, CAAs）是乳腺癌肿瘤微环境（breast cancer tumor microenvironment, TME）的组成成分之一，其体积更小、脂质含量更少、差异标志物表达水平更低，且具有促癌效应。CAAs可分泌多种细胞因子以调控肿瘤细胞，此类细胞因子涵盖激素、白细胞介素与趋化因子。现有研究表明，CAAs可通过分泌CCL5与CCL2促进乳腺癌细胞的恶性进展，但目前针对CCL19与CCR7在乳腺癌中的表达水平及功能的相关研究仍较为有限。鉴于此，本研究拟通过CCL/CCR7趋化因子轴，探究脂肪细胞与乳腺癌细胞之间的相互作用。