Scripts and datasets to generate or analyze data

Chronic venous thrombosis is difficult to treat with current approaches, in part due to its extensive collagen network. Histotripsy is a focused ultrasound therapy that uses bubbles to disrupt tissue, and has several features that make its use for chronic thrombosis attractive. This study used a porcine model to test the hypothesis that portions of chronic thrombosis undergoing active remodeling can be disrupted by histotripsy. Vessels occluded for 30 days were found to be composed primarily of disorganized collagen, and cells that promoted disorganized collagen structures. Histotripsy pressure pulses were able to generate bubbles in all cases, resulting in a 59% mean reduction in the thrombus area. Further, disorganized collagen and cells within the samples were damaged to a greater extent than organized collagen. These data indicate there are chronic venous thrombosis components susceptible to mechanical perturbation by histotripsy despite the extensive collagen.These files were used for analysis of data.慢性静脉血栓（Chronic Venous Thrombosis）的现有治疗方案收效甚微，部分原因在于其富含致密的胶原网络。组织碎石术（Histotripsy）是一种聚焦超声治疗技术，通过气泡实现组织破坏，其多项特性使其应用于慢性血栓治疗颇具潜力。本研究采用猪模型，验证了“处于活跃重塑阶段的慢性血栓部分可被组织碎石术破坏”这一假说。研究发现，闭塞时长30天的血管主要由紊乱型胶原以及促进紊乱胶原结构形成的细胞构成。组织碎石术的压力脉冲在所有实验中均可产生气泡，使血栓面积平均缩小59%。此外，样本内的紊乱型胶原与细胞的受损程度显著高于规整型胶原。上述数据表明，尽管慢性静脉血栓富含致密胶原，但其部分组分仍可被组织碎石术通过机械扰动破坏。本数据集文件用于数据分析。