Evaluation of unilateral corneal collagen cross-linking on fellow untreated eyes of patients with keratoconus

ABSTRACT Purpose: This study aimed to examine the effects of unilateral corneal collagen cross-linking treatment on visual acuity and the topographic findings of the fellow untreated eye of patients who had bilateral progressive keratoconus. Methods: Patients with progressive keratoconus who underwent cross-linking treatment were screened retrospectively. A total of 188 untreated eyes of 188 patients whose eyes were treated unilaterally with either standard or accelerated cross-linking and refused cross-linking procedure for the fellow eye were included. Visual acuity and topographic findings of the fellow untreated eyes were obtained preoperatively and postoperatively at the 1st, 3rd, 6th, 12th, 24th, 30th, and 36th months. Results: The change over time of variables examined was similar in the untreated eyes of patients who received standard and accelerated cross-linking methods (p>0.05). At the 12th month, 136 (95.8%) untreated eyes were stable according to progression criteria. Only 4 (8%) eyes were progressive at the 24th month. No progression was observed in any of the 16 patients with a 36-month follow up. Conclusions: The results showed that the fellow untreated eyes of patients with bilateral progressive keratoconus did not have significant progression rates after unilateral cross-linking treatment.摘要： 研究目的：本研究旨在探讨单侧角膜胶原交联术（corneal collagen cross-linking）对双侧进展性圆锥角膜（keratoconus）患者未接受治疗的对侧眼的视力及地形图表现的影响。 研究方法：本研究回顾性筛选了接受胶原交联术治疗的进展性圆锥角膜患者，最终纳入188例患者的188只未接受治疗的对侧眼——所有入组患者均接受了单侧标准或加速型角膜胶原交联术治疗，且拒绝为其对侧眼实施该手术。研究人员分别于术前及术后第1、3、6、12、24、30、36个月，采集该未接受治疗的对侧眼的视力及地形图相关数据。 研究结果：接受标准型与加速型角膜胶原交联术的患者，其未接受治疗的对侧眼各项观测指标随时间的变化趋势无显著统计学差异（p>0.05）。术后第12个月时，依据病情进展判定标准，136只（95.8%）对侧眼病情保持稳定；术后第24个月时，仅4只（8%）对侧眼出现病情进展；在完成36个月随访的16例患者中，未观察到任何对侧眼病情进展的病例。 研究结论：本研究结果显示，双侧进展性圆锥角膜患者在接受单侧角膜胶原交联术后，其未接受治疗的对侧眼病情进展率无显著升高。