Boronate Ester Bullvalenes

Boronate ester bullvalenes are now accessible in two to four operationally simple steps. This unlocks late-stage diversification through Suzuki cross-coupling reactions to give mono-, di-, and trisubstituted bullvalenes. Moreover, a linchpin strategy enables preprogrammed installation of two different substituents. Analysis of solution phase isomer distributions and single-crystal X-ray structures reveals that isomer preference in the crystal lattice is due to general shape selectivity.硼酸酯布瓦尔烯（boronate ester bullvalenes）现已可通过2至4步操作简便的合成步骤制备。该类化合物可通过铃木-宫浦交叉偶联反应（Suzuki cross-coupling）实现后期多样化修饰，从而得到单取代、二取代及三取代的布瓦尔烯。此外，关键枢纽策略（linchpin strategy）可实现两种不同取代基的预编程引入。对溶液相异构体分布与单晶X射线结构的分析表明，晶格内的异构体偏好性源于普遍存在的形状选择性。