Enantioselective Synthesis of Axially Chiral Multifunctionalized Biaryls via Asymmetric Suzuki–Miyaura Coupling

Substituted 2-formylarylboronic acids were successfully employed
as substrates for asymmetric Suzuki–Miyaura coupling. By virtue
of the coupling with dialkoxyphosphinyl substituted naphthyl bromides
and 2-nitronaphthalen-1-yl triflouromethanesulfonate, a series of
novel multifunctionalized axially chiral biaryls were prepared in
53–97% yields with up to 97% ee using palladium-Cy-MOP as the
catalyst. The methodology provides a highly efficient and practical
strategy for the synthesis of novel multifunctionalized axially chiral
biaryls.