CHARACTERISTICS OF IMMUNOLOGICAL SHIFTS IN COMMUNITY-ACQUIRED PNEUMONIA IN FREQUENTLY ILL CHILDREN

The clinical and immunological status was assessed in 30 children aged 1 to 3 years who developed community-acquired pneumonia. It was revealed that in frequently ill children with community-acquired pneumonia, immunological shifts are characterized by a decrease in CD3, CD4, CD8, LNK16, PHA, IgA, an increase in CD19, IgM, IgG, CIC, which partially persist during the remission period. The decrease in IgA and increase in CIC concentration in blood serum indicate the immunocompromised state of the body and can serve as criteria for early immunodiagnosis of community-acquired pneumonia in frequently ill children.本研究对30名罹患社区获得性肺炎（community-acquired pneumonia）的1至3岁儿童的临床与免疫状态进行了评估。结果显示，在反复罹患社区获得性肺炎的儿童中，免疫状态异常表现为CD3、CD4、CD8、LNK16、植物血凝素（PHA）、免疫球蛋白A（IgA）水平降低，以及CD19、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）、循环免疫复合物（CIC）水平升高，且上述异常在缓解期仍可部分持续存在。血清中IgA水平降低与CIC浓度升高，提示机体处于免疫功能低下状态，可作为反复罹患社区获得性肺炎儿童的社区获得性肺炎早期免疫诊断指标。