XRF analyses to study Analgesic effect of Photobiomodulation Therapy

PhotoBioModulation (PBM) is a novel treatment that exploits laser light at 600-1000 nm to produce analgesia in many clinical conditions. Although PMB use is established, the mechanism of action oi still poorly understood. Evidences indicate that PBM in sensory neurons modulates calcium influx induced by a noxious stimulus. To complement results obtained with conventional studies, the present proposal aims at using XRF microscopy for studying calcium distribution in sensory neurons, before and after laser light stimulation. The analyses will help to improve the understanding and thus the clinical use of PMB for pain