Translation initiation factor 4E in complex with m7G(5'S)ppp(5'S)G mRNA 5' cap analog

Translation initiation factor 4E in complex with m7G(5'S)ppp(5'S)G mRNA 5' cap analog Descriptor: Eukaryotic translation initiation factor 4E, POTASSIUM ION, [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-3~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(3~{R},4~{S})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-phosphinic acid Authors: Warminski, M, Nowak, E, Wojtczak, B.A, Fac-Dabrowska, K, Kubacka, D, Nowicka, A, Sikorski, P.J, Kowalska, J, Jemielity, J, Nowotny, M. Deposit date: 2017-08-18 Release date: 2018-05-02 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.92 Å) Cite: 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. J. Am. Chem. Soc., 140, 2018

结合m7G(5'S)ppp(5'S)G信使RNA（mRNA）5'帽类似物的翻译起始因子4E
描述符：真核翻译起始因子4E、钾离子、[(2S,3S,4R,5R)-5-(2-氨基-7-甲基-6-氧代-3H-嘌呤-7-鎓-9-基)-3,4-二羟基四氢呋喃-2-基]甲硫基-[[[(3R,4S)-5-(2-氨基-6-氧代-1H-嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基]甲硫基-羟基膦酰基]氧基-羟基膦酰基]氧基次膦酸
作者：Warminski M、Nowak E、Wojtczak BA、Fac-Dabrowska K、Kubacka D、Nowicka A、Sikorski PJ、Kowalska J、Jemielity J、Nowotny M
沉积日期：2017-08-18
发布日期：2018-05-02
最后修改：2024-01-17
实验方法：X射线衍射（分辨率1.92埃）
引用文献："5'-硫代磷酸二核苷酸帽类似物：用于信使RNA修饰的试剂与脱帽酶强效小分子抑制剂"，《美国化学会志》，140卷，2018年