CSE-Miner

Immunotherapy with T-cells expressing chimeric antigen receptors (CARs) holds the promise to improve outcomes for children with solid and brain tumors. However, at present, there is a limited array of targetable antigens. We posit here that targets generated by alternative splicing events in cancer cells present an untapped class of CAR targets since many of these are tumor-specific and overexpressed in malignant cells.Thus, we developed Cancer-Specific Exon Miner (CSE-Miner), a pipeline for mining exon-based CAR-T targets嵌合抗原受体（chimeric antigen receptors, CARs）T细胞免疫治疗，有望改善实体瘤与脑肿瘤儿童患者的预后。然而当前可靶向抗原的种类极为有限。本研究提出如下假设：癌细胞中由可变剪接事件产生的靶点，属于一类尚未被开发的CAR靶点，因其多数具备肿瘤特异性且在恶性细胞中过表达。据此，我们开发了癌症特异性外显子挖掘器（Cancer-Specific Exon Miner, CSE-Miner）——一款用于挖掘基于外显子的CAR-T靶点的分析流程。

搜集汇总

背景与挑战

背景概述

CSE-Miner是一个用于挖掘癌症特异性外显子的数据集，旨在为CAR-T免疫疗法提供新的肿瘤特异性靶点。该数据集通过分析癌症细胞中的可变剪接事件，帮助识别在恶性细胞中过表达的外显子靶标。