Reported PRO rationale (items 2a and P2b) and authors’ interpretation of PRO in relation to clinical findings (items P20/21 and 22) in primary reports of trials with separate primary and supplemental papers.

Extracted text was abridged where appropriate, as indicated by a series of periods (…), but otherwise presented verbatim.提取所得的文本已在适当位置进行删节，删节处以省略号（…）标注，其余内容均按原文原样保留。