Supplementary Material for: A Role of Remote Organs Effect in Acute Kidney Injury Outcome?

Acute kidney injury (AKI) has been associated with both short- and long-term outcomes. To date, there is still a debate whether the increase risk of morbidity and mortality is directly due to AKI occurrence. There is, however, a potential causal impact of AKI on outcome, but evidence of this association is yet lacking. The hypothesis of remote organ damage and dysfunction (heart, lung, liver, brain, etc.) has emerged over the last decade and may explain the reason for the potential negative impact of AKI on outcome. The aim of this review was to describe findings concerning the remote effect of AKI in animal models and human studies.急性肾损伤（Acute Kidney Injury，AKI）与短期及长期临床转归均存在关联。迄今为止，学界对于发病率与死亡率升高的风险是否直接由急性肾损伤发作所导致，仍存在争议。然而，急性肾损伤可能对临床转归存在潜在的因果影响，但目前仍缺乏证实该关联的相关证据。近十年来，远隔器官损伤与功能障碍（心脏、肺脏、肝脏、大脑等）的假说应运而生，该假说或可解释急性肾损伤对临床转归产生潜在负面影响的原因。本综述旨在阐述急性肾损伤在动物模型与人体研究中所展现的远隔效应相关研究结果。