Anxiety, depression, health seeking behaviour and consulting for chronic pain in relation to the val158met COMT polymorphism among patients with IBS.

There was no significant difference in age, BMI, HADS scores, health seeking behavior and consulting for chronic pain between different genotypes among 70 patients (61 women) with IBS. However, the val/met carriers tended to have less HADS-depression score compared to the other genotypes and the met/met genotype tended have more visits per year in primary care and more chronic neck pain. BMI = Body mass index. HADS = Hospital anxiety depression scale. ns = Non-significant.*Statistically significant: p针对70名肠易激综合征（Irritable Bowel Syndrome, IBS）患者（其中女性61名）的分析显示，不同基因型患者在年龄、身体质量指数（Body Mass Index, BMI）、医院焦虑抑郁量表（Hospital Anxiety and Depression Scale, HADS）评分、就医行为及慢性疼痛就诊情况方面均无显著差异。然而，缬氨酸/甲硫氨酸（val/met）基因型携带者的HADS抑郁维度评分较其他基因型患者偏低，而甲硫氨酸/甲硫氨酸（met/met）基因型患者的年度基层医疗就诊次数更多，且慢性颈痛发生率更高。BMI=身体质量指数（Body Mass Index），HADS=医院焦虑抑郁量表（Hospital Anxiety and Depression Scale），ns=无统计学显著性（Non-significant）。*具有统计学显著性：p