Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains superficial. Here, using singl
How epigenetic changes contribute to MS pathogenesis is still poorly understood. Therefore, we conducted a comprehensive analysis of genome-wide DNA methylation patterns in four immune cell population
Multiple sclerosis (MS) is a T cell-mediated demyelinating autoimmune disease of the central nervous system causing neurological deficits with substantial disability. Our group demonstrated that self-
(a) In a previous study, 4 out of 17 patients responded to MBP with CD4+ T-cell proliferation ex vivo [21]. By DNA array analysis of gene expression [18], we found that 75 out of 3284 genes were more