P1' Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

P1' Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold Descriptor: POL PROTEIN, {(1S)-1-[N'-[(2S)-2-HYDROXY-2-((1S,2R)-2-HYDROXY-INDAN-1-YLCARBAMOYL)-3-PHENYL-PROPYL]-N'-[4-(PYRIDINE-2-YL)-BENZYL]-HYDRAZINOCARBONYL]-2,2-DIMETHYL-PROPYL}-CARBAMIC ACID METHYL ESTER Authors: Ginman, N, Ekegren, J.K, Johansson, A, Wallberg, H, Larhed, M, Samuelsson, B, Hallberg, A, Unge, T. Deposit date: 2006-02-08 Release date: 2007-02-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Microwave-Accelerated Synthesis of P1'-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold. J.Med.Chem., 49, 2006

P1'延伸型HIV-1蛋白酶抑制剂描述符（包含过渡态模拟支架（Transition-State Mimicking Scaffold）中的叔醇（Tertiary Alcohol）结构）：POL蛋白，{(1S)-1-[N'-[(2S)-2-羟基-2-((1S,2R)-2-羟基-茚满-1-基氨基甲酰基)-3-苯基-丙基]-N'-[4-(吡啶-2-基)-苄基]-肼基羰基]-2,2-二甲基-丙基}-氨基甲酸甲酯。作者：Ginman, N、Ekegren, J.K、Johansson, A、Wallberg, H、Larhed, M、Samuelsson, B、Hallberg, A、Unge, T。存储日期：2006-02-08，发布日期：2007-02-13，最后修改日期：2023-12-13。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.8埃）。引用文献：《微波辅助合成包含过渡态模拟支架中叔醇结构的P1'延伸型HIV-1蛋白酶抑制剂》，《药物化学杂志》（J.Med.Chem.），2006年，第49卷