Summary of several variants of the variant allele frequency factorization problem studied in the literature.
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The loss functions L(F, U, B) and additional constraints beyond are noted for each method. Due to space constraints, we do not describe the regularization term(s) appearing in the loss function for several methods [6–9, 11], which penalize the total number of mutation clusters. *CALDER enforces an additional hard constraint that the inferred matrices are longitudinally consistent, when provided with additional longitudinal information.
创建时间：
2024-12-04
