Age and sex adjusted and hazard rate ratios (HR) for CRC characterized by CIMP and MSI, according to three time periods of energy restriction in the Netherlands Cohort Study on diet and cancer (7.3 years of follow-up).

*reference category.†category created from combining individuals who lived in a western rural area and a western urban area.‡ Hunger Winter: it was assumed that individuals residing in a western area of the Netherlands, especially a western urban area during the Hunger Winter would have experienced the greatest degree of energy restriction; War Years: it was assumed that individuals who resided in an urban area during the mid-point of the War would have experienced the greatest degree of energy restriction; Economic Depression: it was assumed that individuals who had an unemployed father during the Economic Depression would have experienced a higher degree of energy restriction compared to those whose father was employed.