Age and sex adjusted and hazard rate ratios (HR) for CRC characterized by CIMP and MSI, according to three time periods of energy restriction in the Netherlands Cohort Study on diet and cancer (7.3 years of follow-up).

*reference category.†category created from combining individuals who lived in a western rural area and a western urban area.‡ Hunger Winter: it was assumed that individuals residing in a western area of the Netherlands, especially a western urban area during the Hunger Winter would have experienced the greatest degree of energy restriction; War Years: it was assumed that individuals who resided in an urban area during the mid-point of the War would have experienced the greatest degree of energy restriction; Economic Depression: it was assumed that individuals who had an unemployed father during the Economic Depression would have experienced a higher degree of energy restriction compared to those whose father was employed.* 参考类别。 † 该类别由居住于西部农村与西部城市的个体合并构建而成。 ‡ 饥饿冬季（Hunger Winter）：研究假设，居住于荷兰西部地区、尤其是饥饿冬季期间的西部城市区域的个体，承受了最严重的能量限制；战争年代（War Years）：假设在战争中期居住于城市区域的个体，经历了最为严重的能量限制；经济大萧条（Economic Depression）：假设在经济大萧条期间父亲处于失业状态的个体，相较父亲拥有工作的个体，承受了更高程度的能量限制。