Bulk Omni-ATAC-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types

To understand how age rewires the chromatin accessibility landscape, we molecularly profiled 23 purified cell types from 11 tissues and organs by assessing the cumulative signature of 15-25 young and aged mice for robust difference detection. We performed Omni-ATAC-seq for young (2 months) and aged (22-24 months) mice for FACS sorted cell-types. For sequencing of libraries derived from primary cell samples the DNBSEQ-G400 instrument (Bejing Genomics Institute) was used for ATAC-seq libraries (100 bp paired end mode).