(Elhossiny et al, Cancer Discovery, 2026) Processed Data Objects

This is the processed scRNAseq and spatial transcriptomics data from the study Ahmed M. Elhossiny, Padma Kadiyala, Jude Ogechukwu. Okoye, Harrison L. Hiraki, Megan C. Procario, Thejaswini Giridharan, Hannah R. Watkoske, Mariana Tannus Ruckert, Jiayue Wang, Brian D. Griffith, Alexander W. Bray, Jamie N. Mills, Carlos E. Espinoza, Jörg Zeller, Nicole Peterson, Filip Bednar, Yaqing Zhang, Arvind Rao, Costas A. Lyssiotis, Julianne M. Szczepanski, Jiaqi Shi, Atul Deshpande, Anirban Maitra, Elana J. Fertig, Eileen S. Carpenter, Timothy L. Frankel, Marina Pasca di Magliano; Asynchronous evolution of epithelium and stroma differentiates precursor lesions from pancreatic cancer. Cancer Discov 2026; https://doi.org/10.1158/2159-8290.CD-25-2001 Interactive exploration of the data: www.pancreas-precaner-atlas.com Data objects Description scRNAseq data scRef.rds : scRNAseq data from donor pancreas, adjacent normal, and PDAC samples scRef_macs.rds : Macrophages subclusters from scRNAseq scRef_fibro.rds : Fibroblasts subclusters from scRNAseq organoids_cocultures_scRNAseq.rds : scRNAseq data from (tumor organoids / normal fibroblasts / CAFs) either monocultured or cocultured Spatial Data (Visium) spatial.rds : Visium data from donor pancreas, adjacent normal, and PDAC samples donor_spatial_validation.rds : Visium data from additional donor pancreas used for validation of initial findings pseudobulk_macs.rds : Macrophages-specific expression from macrophages spatial domains in Visium data pseudobulk_fibro.rds : Fibroblast-specific expression from the fibroblast spatial domains (Fibro2/Fibro3) in Visium data pseudobulk_epi.rds : Tumor-epithelial-specific expression from the PanINs/GLTumor/PDTumor spatial domains in the Visium data Spatial Data (Reprocessed Xenium) bell_et_al_reprocessed_Xenium_data.rds : Reprocessed Xenium data from Bell et al, 2024 fiorini_et_al_reprocessed_Xenium_data.rds : Reprocessed Xenium data from Fiorini et al, 2025 fiorini_et_al_proseg_segmentation_polygons.zip : Cells polygons from the segmentation analysis done using Proseg on Xenium data from Fiorini et al, 2025 bell_et_al_proseg_segmentation_polygons.zip : Cells polygons from the segmentation analysis done using Proseg on Xenium data from Bell et al, 2024