Identified Studies.

BackgroundAbdominal aortic aneurysm (AAA) has a high mortality rate after rupture. This study systematically explored the risk factors associated with AAA in the general population using a meta-analytic approach.Materials and methodsWe conducted a systematic search of PubMed, Embase, and Cochrane Library databases to identify relevant literature. The search was conducted through May 2025. Factors considered in more than three studies were included in the analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were used as effect estimates and all pooled analyses were performed using a random-effects model.ResultsThirty-four studies reporting 34,551 AAA cases were selected for meta-analysis. Increased risk of AAA was associated with male (OR: 3.78; 95% CI: 2.80–5.10; P P P P P P P P P = 0.001) and family history of AAA (OR: 2.26; 95% CI: 1.58–3.25; P P = 0.007). Furthermore, the risk of AAA was not affected by advanced age, alcohol intake, cancer, being overweight, or physical activity. The association between AAA risk and sex, smoking, hypertension, diabetes mellitus, renal disease, and a family history of AAA differs between Eastern and Western countries.ConclusionsWe systematically explored the risk factors for AAA. AAA represent a significant public health concern. Thus, early intervention and health education targeting these risk factors are necessary to prevent their occurrence. Registration: INPLASY2023120024背景：腹主动脉瘤（Abdominal aortic aneurysm, AAA）破裂后死亡率极高。本研究采用荟萃分析方法，系统探讨了普通人群中与腹主动脉瘤相关的危险因素。 材料与方法：系统检索PubMed、Embase及Cochrane Library数据库以识别相关文献，检索时限截至2025年5月。纳入分析的危险因素需在至少3项研究中被报道。以比值比（Odds ratios, OR）及95%置信区间（confidence intervals, CI）作为效应量指标，所有合并分析均采用随机效应模型进行。 结果：最终纳入34项报告34551例腹主动脉瘤病例的研究进行荟萃分析。研究显示，男性（OR: 3.78; 95% CI: 2.80–5.10; P < 0.001）、吸烟、高血压、糖尿病、肾病及腹主动脉瘤家族史（OR: 2.26; 95% CI: 1.58–3.25; P = 0.007）与腹主动脉瘤风险升高相关。此外，高龄、饮酒、癌症、超重及体力活动与腹主动脉瘤风险无显著关联。腹主动脉瘤风险与性别、吸烟、高血压、糖尿病、肾病及腹主动脉瘤家族史之间的关联存在东西方国家差异。 结论：本研究系统探讨了腹主动脉瘤的危险因素。腹主动脉瘤是一项重要的公共卫生问题，因此针对上述危险因素开展早期干预及健康教育对于预防其发生具有必要性。 本研究注册编号：INPLASY2023120024