Parameters of our two-scale migration model.

References that support the parameters are given where available. The entry rates into LNs and spleen are not experimental estimates but are adopted from earlier modeling work [17]. However, these values accurately predict the T cell distribution over the organs at steady state, the blood residence time and the blood-to-lymph transit time (Table 2). The geometric parameters (T cell zone radius in LN and spleen, aperture radius in spleen) were set to values that are both anatomically reasonable and give realistic mean dwell times in LNs and spleen. The parameters shown in this table were used for all simulation results reported in this paper unless otherwise indicated. (*) The axillary, brachial and inguinal LNs are represented by 2 spheres each, while the mesenteric LN is represented by 4 spheres. Thus, in total, we have 39 spheres.如有可用来源，本研究将列出支撑各参数的参考文献。淋巴细胞进入淋巴结（Lymph Nodes, LNs）及脾脏的迁移速率并非实验估算值，而是引自前期建模研究[17]。但该类参数可精准预测稳态下各器官内的T细胞分布、血液驻留时间以及血液-淋巴转运时间（见表2）。几何参数（淋巴结及脾脏内T细胞区半径、脾脏孔径半径）的取值既符合解剖学合理性，又能模拟出淋巴结与脾脏内符合实际情况的平均驻留时长。除非另有说明，本文报告的所有仿真结果均采用本表所列参数。(*) 腋窝淋巴结、臂淋巴结及腹股沟淋巴结各以2个球体表征，而肠系膜淋巴结以4个球体表征。综上，总计共39个球体。