Data Sheet 1_Effects of intermittent pneumatic compression device on the improvement of tissue oxygen saturation and fluid clearance at the compression site.docx

IntroductionIntermittent pneumatic compression devices (IPCDs) facilitate post-exercise recovery by increasing tissue oxygen saturation (rSO2) and reducing intramuscular interstitial fluid. However, limited evidence exists on time-course changes of these physiological responses during the intervention. This study aimed to examine the effects of IPCD use on rSO2 and fluid content in the lower limbs.
MethodsWe enrolled 59 healthy adults (37 males, 22 females) who underwent a 30-min IPCD intervention on their right leg at a target pressure of 90 mmHg. The rSO2 at the posterior calf was measured using near-infrared spectroscopy at baseline and across four periods (period 1: 0.5–3.5 min; period 2: 10–13 min; period 3: 20–23 min; and period 4: 27–30 min). T2-weighted magnetic resonance imaging was conducted pre- and post-intervention to assess fluid clearance.
ResultsThe rSO2 values increased significantly from baseline (75.7% ± 5.8%) across all time periods (period 1: 79.5% ± 4.7%; period 2: 80.5% ± 4.7%; period 3: 80.8% ± 4.7%; and period 4: 81.2% ± 4.8%; p < 0.001). The values in periods 2, 3, and 4 were significantly higher than those in period 1 (p < 0.001), with no significant differences observed among periods 2, 3, and 4. Moreover, the T2 values significantly decreased post-intervention (Pre: median, 39.3; Post: 37.9; p < 0.001).
ConclusionIPCD use improves muscle oxygen saturation and facilitates fluid clearance within 30 min. Although oxygenation effects occur early, a 30-min IPCD session provides both oxygenation and fluid reduction benefits.