Crystal structure of the Abl 1b Kinase domain in complex with Dasatinib and Imatinib
收藏Protein Data Bank Japan2023-10-18 更新2026-03-28 收录
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Crystal structure of the Abl 1b Kinase domain in complex with Dasatinib and Imatinib Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, PHOSPHATE ION, ... Authors: Miller, D.J, Xie, T. Deposit date: 2021-06-17 Release date: 2022-04-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Imatinib can act as an Allosteric Activator of Abl Kinase. J.Mol.Biol., 434, 2022
达沙替尼（Dasatinib）与伊马替尼（Imatinib）复合的Abl 1b激酶结构域晶体结构
描述物：4-(4-甲基哌嗪-1-基甲基)-N-[4-甲基-3-(4-吡啶-3-基嘧啶-2-基氨基)苯基]苯甲酰胺、N-(2-氯-6-甲基苯基)-2-({6-[4-(2-羟乙基)哌嗪-1-基]-2-甲基嘧啶-4-基}氨基)-1,3-噻唑-5-甲酰胺、磷酸根离子……
作者：Miller, D.J.、Xie, T.
提交日期：2021-06-17
发布日期：2022-04-27
最后修改日期：2023-10-18
实验方法：X射线衍射（分辨率2.2埃）
引用文献：伊马替尼可作为Abl激酶的变构激活剂，J.Mol.Biol., 434, 2022
创建时间：
2021-06-17
