Supplementary tables 5-17 - Data tables generated during RNA-seq and ChIP-seq analysis, and the information on the siRNA screens. from BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation
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Table S5. The list of genes significantly altered in H446 cells after NEUROD1 KO. Table S6. The list of NEUROD1 peaks identified in H446 control cells (control gRNA, cl.10) Table S7. The list of NEUROD1 target genes identified by BETA. Table S8. Gene Descriptions Table S9. The list of genomic regions singly occupied by BRD4 in H446 control cells (control gRNA cl. 10). Table S10. The list of genes with significantly altered expression after JQ1 treatment (24 hrs, 1µM) in H446 control cells (control gRNA cl.10). Table S11. The list of genes with significantly altered expression after JQ1 treatment (24 hrs, 1µM) in H446 NEUROD1-KO cells (#297 cl.2-1). Table S12. The list of genes with significantly altered expression after JQ1 treatment (24 hours at 0.5µM) in COR-L279 cells. Table S13. The list of NEUROD1-loaded superenhancers in H446 control cells (control gRNA cl.10). Table S14. The list of BRD4-loaded superenhancers in H446 control cells (control gRNA cl.10). Table S15. The list of BRD4-loaded superenhancers in H446 NEUROD1-KO cells (#297 cl.2-1). Table S16. Information on the Qiagen custom siRNA library. Table S17. The list of genes with significantly altered expression in SCLC PDX LX22 following 5-day NHWD-870 treatment (3mg/kg via gavage daily; n=6 /group).
Table S5. H446细胞经神经源性分化因子1（NEUROD1）敲除后显著差异表达的基因列表。 Table S6. 在H446对照细胞（对照向导RNA（gRNA）克隆10）中鉴定到的NEUROD1结合峰列表。 Table S7. 通过BETA鉴定到的NEUROD1靶基因列表。 Table S8. 基因功能注释表。 Table S9. H446对照细胞（对照gRNA克隆10）中仅由溴结构域蛋白4（BRD4）单一位点结合的基因组区域列表。 Table S10. H446对照细胞（对照gRNA克隆10）经JQ1处理（24小时，1µM）后显著差异表达的基因列表。 Table S11. H446 NEUROD1敲除细胞（#297克隆2-1）经JQ1处理（24小时，1µM）后显著差异表达的基因列表。 Table S12. COR-L279细胞经JQ1处理（24小时，0.5µM）后显著差异表达的基因列表。 Table S13. H446对照细胞（对照gRNA克隆10）中结合有NEUROD1的超级增强子列表。 Table S14. H446对照细胞（对照gRNA克隆10）中结合有BRD4的超级增强子列表。 Table S15. H446 NEUROD1敲除细胞（#297克隆2-1）中结合有BRD4的超级增强子列表。 Table S16. 凯杰（Qiagen）定制小干扰RNA（siRNA）文库信息。 Table S17. 小细胞肺癌（SCLC）患者来源的异种移植模型（PDX）LX22经5天NHWD-870治疗（每日灌胃3mg/kg，每组n=6）后显著差异表达的基因列表。
