Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-781
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Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-781 Descriptor: 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-N-(propane-2-sulfonyl)propanamide, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-02-09 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-781 to be published
结核分枝杆菌（Mycobacterium tuberculosis）二氢叶酸还原酶（Dihydrofolate reductase）结合烟酰胺腺嘌呤二核苷酸磷酸（NADP, NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）与SDDC抑制剂SDDC-781的晶体结构，配体描述符：3-(2-{3-[(2,4-二氨基-6-乙基嘧啶-5-基)氧基]丙氧基}苯基)-N-(丙烷-2-磺酰基)丙酰胺，相关组分：二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸（NADP）
作者：西雅图传染病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID）
提交日期：2021-12-20
发布日期：2022-02-09
最后修改日期：2024-05-22
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.55埃（Å）
引用说明：结合NADP与SDDC抑制剂SDDC-781的结核分枝杆菌二氢叶酸还原酶晶体结构，待发表。
创建时间：
2021-12-20
