The Search for Novel Proline Analogs for Viscosity Reduction and Stabilization of Highly Concentrated Monoclonal Antibody Solutions: Structures and properties of selected proline-based compounds and relative viscosity of the samples containing test compounds

The table is the supporting information for a journal article with data about the structures and physico-chemical properties of the selected compounds that were tested as viscosity-reducing compounds in the research. The table includes the measured viscosity of the model monoclonal antibody solution containing the tested compounds at 25 mM concentration (sample solution), which was measured at 25 °C using a viscometer-rheometer (RheoSense m-VROC, Viscometer/Rheometer-On-a-Chip) based on microfluidic and MEMS (Micro-Electro-Mechanical systems) technologies using the A05 chip. In addition, it includes the viscosity that the solution of the model monoclonal antibody has at the concentration of the sample solution (baseline viscosity) and the relative viscosity calculated as the viscosity of the sample solution divided by the baseline viscosity (relative viscosity), which represents the viscosity-reducing effect of the test compound. The potential toxicity of the test compounds has also been evaluated with the knowledge-based expert system Nexus Derek (Lhasa Limited, Leeds, UK) and its knowledge base Derek KB 2020 1.0 and is included in the table.本表格为某期刊论文的补充材料，收录了本研究中作为减粘化合物开展测试的目标化合物的结构与理化性质相关数据。本表格包含了添加浓度为25 mM受试化合物的模型单克隆抗体溶液（即样品溶液）的实测粘度数据；该粘度采用基于微流控技术与微电子机械系统（Micro-Electro-Mechanical systems，MEMS）的粘度流变仪（RheoSense m-VROC，芯片式粘度/流变仪），搭配A05芯片，于25℃条件下测得。此外，表格还收录了对应样品溶液浓度的模型单克隆抗体溶液的粘度（即基线粘度），以及以样品溶液粘度除以基线粘度计算得到的相对粘度（relative viscosity），该指标可表征受试化合物的减粘效果。受试化合物的潜在毒性已通过基于知识的专家系统Nexus Derek（英国利兹Lhasa有限公司）及其知识库Derek KB 2020 1.0完成评估，相关结果亦收录于本表格中。