Crude and adjusted rate ratios of cancer associated with antihypertensive agents relative to diuretic and/or beta-blocker use.

Abbreviations: RR, rate ratio; CI, confidence interval; ARB, angiotensin receptor blocker; ACEI, angiotensin-converting enzyme inhibitor; CCB, calcium channel blocker; DDD, defined daily doses.
*Cases and controls were matched on year of birth, year of cohort entry, sex, prevalent user status, and duration of follow-up.
†Adjusted for excessive alcohol use, body mass index, smoking, diabetes, previous cancer, and ever of aspirin, statins, and NSAIDs.
‡Defined as receiving prescriptions for both agents on the same day on at least one occasion.
§Dose-response analyses conducted among the 5583 cases and 56,817 controls exposed to ARBs. Categories based on tertiles.