Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(2-((3-(thiophene-2-carboximidamido)benzyl)amino)ethyl)phenyl)thiophene-2-carboximidamide

Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(2-((3-(thiophene-2-carboximidamido)benzyl)amino)ethyl)phenyl)thiophene-2-carboximidamide Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-(3-{2-[(3-{[(Z)-imino(thiophen-2-yl)methyl]amino}benzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide, ... Authors: Li, H, Poulos, T.L. Deposit date: 2013-04-24 Release date: 2014-02-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J.Med.Chem., 57, 2014

与N-(3-(2-((3-(噻吩-2-甲亚酰胺基)苄基)氨基)乙基)苯基)噻吩-2-甲亚酰胺结合的神经元型一氧化氮合酶（neuronal nitric oxide synthase）血红素结构域的晶体结构。组成成分：5,6,7,8-四氢生物蝶呤（5,6,7,8-TETRAHYDROBIOPTERIN）、乙酸根离子（acetate ion）、N-(3-{2-[(3-{[(Z)-亚氨基(噻吩-2-基)甲基]氨基}苄基)氨基]乙基}苯基)噻吩-2-甲亚酰胺，…… 作者：Li, H、Poulos, T.L. 提交日期：2013-04-24 发布日期：2014-02-12 最后更新日期：2023-09-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.1埃 引用文献：《用于黑色素瘤治疗的强效且选择性双头噻吩-2-甲亚酰胺类神经元型一氧化氮合酶抑制剂》，《J. Med. Chem.》，57卷，2014年。