Crystal structure of the mutant R160A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Crystal structure of the mutant R160A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP Descriptor: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. Deposit date: 2012-07-29 Release date: 2013-06-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4204 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry, 51, 2012

热自养甲烷杆菌（Methanobacterium thermoautotrophicum）来源的乳清苷5'-单磷酸脱羧酶（orotidine 5'-monophosphate decarboxylase）突变体R160A·R203A与抑制剂BMP结合的晶体结构，该抑制剂的化学标识为6-羟基尿苷5'-磷酸（6-HYDROXYURIDINE-5'-PHOSPHATE）。作者：Fedorov, A.A.、Fedorov, E.V.、Desai, B.、Gerlt, J.A.、Almo, S.C. 提交日期：2012-07-29 发布日期：2013-06-19 最后修改日期：2023-09-13 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.4204 Å。引用文献：《乳清苷5'-单磷酸脱羧酶的构象变化：基于结构阐释5'-磷酸基团如何激活该酶》，《生物化学（Biochemistry）》，第51卷，2012年。