The urinary microbiome in patients with refractory urge incontinence and recurrent urinary tract infection

Urinary urge incontinence is a chronic, debilitating condition that is difficult to treat. Patients refractory to standard antimuscarinic therapy often experience recurrent urinary tract infections (rUTIs). The microbiota of these refractory patients with rUTI remains unexplored. Here we applied culture-independent sequencing in combination with standard diagnostic microbiology to investigate changes in the urine microbiota of women with urodynamically proven refractory detrusor overactivity and concomitant UTI over a 2-year time period. The data presented here are raw reads from 16S amplicon sequencing.