Between-group comparison. Timepoint 12 = After 12 weeks of intervention, Timepoint 16 = After 16 weeks for follow-up, * Significant in per-protocol analysis, † remained statistically significant in the sensitivity analysis.

Between-group comparison. Timepoint 12 = After 12 weeks of intervention, Timepoint 16 = After 16 weeks for follow-up, * Significant in per-protocol analysis, † remained statistically significant in the sensitivity analysis.组间比较。时间点12：干预12周后；时间点16：随访16周后。* 符合方案集分析中具有统计学显著性；† 敏感性分析中仍保持统计学显著性。