The role of AR associated protein and lncRNA in androgen signaling

Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. To investigate the AR signaling, we performed RNA sequence analysis in AR positive prostate cancer cell line, LNCaP. In addition, we used hormone-refractory prostate cancer model cells, Long term androgen deprivation (LTAD) to explore the differences of androgen signaling in prostate cancer progression. We analyzed the role of PSF, CTBP1-AS and COBLL1 which we identified as regulators of androgen signaling. Overall design: RNA sequence analysis of androgen-regulated genes in two prostate cancer cells